It is a known fact the Parkinson’s disease or PD has no cure. In the early stages of uncomplicated Parkinson’s disease, the use of pharmacological agents is still the primary mode of treatment and also the most common therapy for PD. Aside from levodopa, dopamine agonists are the other recommended antiparkinson drugs during the early stages of the disease. There are 3 dopamine agonists which are commercially available in the Philippines, namely:
BROMOCRIPTINE MESYLATE
NOVARTIS HEALTHCARE
[ZUELLIG] {P141.50}
PRAMIPEXOLE diHCl
(SIFROL)
BOEHRINGER INGELHEIM
[METRO DRUG]
{P151.00} of 1 mg/tab
PIRIBEDIL
(TRIVASTAL RETARD 50)
SERVIER
[ZUELLIG]
{P38.50}
LEGEND:
GENERIC NAME
(BRAND NAME)
MANUFACTURER
[DISTRIBUTOR]
{SUGGESTED RETAIL PRICE}
However, I will only discuss one of the three dopamine agonists ,PRAMIPEXOLE, which is a non-ergot derivative.
What are the INDICATIONS for the use of pramipexole?
1. Treatment of signs and symptoms of idiopathic Parkinson's disease
2. As monotherapy or in combination with levodopa
3. Symptomatic treatment of idiopathic restless leg syndrome
What is the usual DOSAGE of pramipexole?:
1. Parkinson's disease
Week 1 - 0.125 mg 3x a day
Week 2 - 0.25 mg 3x a day
Week 3 - 0.5 mg 3x a day
Maximum 4.5 mg/day
2. Restless Leg Syndrome
Step 1: 0.125 mg
Step 2: 0.25 mg
Step 3: 0.5 mg
Step 4: 0.75 mg (Maximum dose)
All doses taken once daily 2-3 hours before bedtime. If needed, titrate to each step every 4-7 days.
How do you ADMINISTER oral Pramipexole?
Pramipexole may also be taken with meals to minimize gastrointestinal upset.
What are the SPECIAL PRECAUTIONS in the use of parmipexole?
The dose must be reduced in patients with renal impairment or creatinine clearance (CrCl) of less than 50 ml/min.
What are the ADVERSE REACTIONS of pramipexole? (DiCoFISHPEN)
1. Dizziness
2. Dyskinesia
3. Constipation
4. Confusion
5. Falling asleep during activities of daily living
6. Insomnia
7. Somnolence
8. Hallucination
9. Peripheral edema
10. Nausea
What are the PREPARATIONS of pramipexole?
Pramipexole is available in either 250 mcg/tab or 1 mg/tab.
To learn more about the recent updates in the diagnosis and management of Parkinson's disease, attend the first annual convention of Pinoy PD, entitled: "HEALING OF PARKINSON'S DISEASE THRU G-MEN (GOD, MEDICINE, EXERCISE and NUTRITION).
P.S. Register for FREE on or before September 30, 2011.
P.P.S. Register for a GUARANTEED SEAT and SLOT in the workshop to a LIMITED NUMBER of participants on or before September 30, 2011.
P.P.P.S. Submit REGISTRATION DETAILS (Name, Age, Contact number and E-mail address) on or before September 30, 2011 to avail of FREE REGISTRATION and send via email to drajoy31@yahoo.com / drajoy31@gmail.com
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